Transcription-replication Conflicts In Disease And Development

  Address - Cayman Islands

  Contact details - 565656565

  Tender notice no. - 76454545

  MT Ref Id - 10120415

  Document Type - Tender Notices

Description - Status : Grant agreement signedOverall budget : € 1 497 530EU contribution : € 1 497 530Genetic and epigenetic instability contribute to cancers, aging, developmental disorders, and neurological diseases, so in-depth understanding how this instab ility arises is an important question affecting millions in Europe. Physical conflicts between the transcription and DNA replication machineries are a potent endogenous source of this instability.My preliminary data indicate that a single collision can trigger long-term epigenetic changes and affect the normal expression state of genes. I hypothesize that collisions can rewire gene expression networks and lead to cellular transformations relevant

Mt Ref Id - 10120415

Deadline - Jan 31, 2025