Regulation Of Extreme Plasticity In Planarian Stem Cells By Mrna Modifications

  Address - Israel

  Contact details - 565656565

  Tender notice no. - 76454545

  MT Ref Id - 10099900

  Document Type - Tender Notices

Description - Status : Grant agreement signedOverall budget : € 1 487 500EU contribution : € 1 487 500Planarians are freshwater flatworms that can regenerate any part of their body including an entire head. A single transplanted planarian pluripotent stem cell can rescue a lethally irradiated animal. Hence, the extreme plasticity of planarian stem cells (neoblasts) is critical for regeneration. Despite intensive research, we still do not understand how cellular mechanisms that regulate neoblast homeostasis are integrated to facilitate regeneration. In a preliminary study, I discovered that chemical modifications of nucleic acids are critical for normal neoblast function, and that animals lacking this

Mt Ref Id - 10099900

Deadline - Oct 31, 2024