Multivalent Interactions Driving Rnp Dynamics In Development And Disease

  Address - Slovenia

  Contact details - 565656565

  Tender notice no. - 76454545

  MT Ref Id - 10110354

  Document Type - Tender Notices

Description - Status : Grant agreement signedOverall budget : € 2 396 261,25EU contribution : € 2 396 261,25ObjectiveRibonucleoprotein complexes (RNPs) play many key regulatory roles in development. Moreover, mutations causing cancer or neurodegenerative disea ses, such as amyotrophic lateral sclerosis (ALS), often occur in RNA-binding proteins (RBPs). These mutations are concentrated in the intrinsically disordered regions (IDRs), which play a central role in the control of RNP assembly and disassembly. RNP dynamics is often driven by multivalent interactions that are mediated by multiple elements within IDRs of RBPs, which can condense the RNP such that it separates from the surrounding liquid throug

Mt Ref Id - 10110354

Deadline - Dec 31, 2024